Research report 2009 - Max Planck Research Unit for Enzymology of Protein Folding
cyclophilines and cancer
Authors
Schiene-Fischer, Cordelia
Departments
Hitzeschockproteine als enzymatische Faltungskatalysatoren (Dr. Cordelia Schiene-Fischer)
MPF für Enzymologie der Proteinfaltung, Halle/Saale
Summary
The human peptidyl-prolyl cis/trans isomerase (PPIase) cyclophilin A interacts with the tumor suppressor protein p53, whereas the highly related human cyclophilin B specifically interacts with the transcription factor Stat3. In vivo data suggest functional importance of both interactions observed. Thus, cyclophilin A and cyclophilin B both are involved, yet at different signaling levels, in cell signaling processes related to cancer development.