Research report 2008 - Max Planck Institute of Biochemistry
Structural analysis of dynamic virus-host-interactions
Zelluläre Infektion durch Viren (Grünewald, Abteilung Molekulare Strukturbiologie, DFG/Emmy Noether) (Dr. Kay Grünewald)
MPI für Biochemie, Martinsried
SummaryThe structure of viruses provides a remarkable example of simplicity and functionality in biological systems. Composed of a limited number of proteins and often organized according to geometric principles, viral particles are effective devices in the transfer of the viral genome and proteins to host cells. To determine the molecular interactions, cryo electron tomography is employed to reveal the molecular players through which viruses communicate with their hosts and to understand how viruses take advantage of cellular cues in infection and for replicating themselves efficiently.