Research report 2009 - Max Planck Institute for Medical Research
Hippocampus and spatial short- and longterm memory
Seeburg, Peter H.; Sprengel, Rolf
Abteilung Molekulare Neurobiologie; Gruppe Rolf Sprengel
SummaryGlutamate is the most prevalent neurotransmitter at excitatory synapses of our nervous system and thus indispensable for the activity and accomplishments of our brain. Genetic manipulations in the model organism mouse permit an evaluation of the role of synaptic key components activated by glutamate in spatial learning paradigms. A mouse mutant reveals that a particular synaptic component is essential for a sense of familiarity with a recently encountered spatial environment, and hence functions as a molecular building block in learning and memory.