Research report 2023 - Max Planck Institute of Molecular Cell Biology and Genetics
A map to study the behavior of early pancreas cells
Authors
Grapin-Botton, Anne; Beydag-Tasöz, Belin Selcen
Departments
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Dresden
Summary
Anne Grapin-Botton’s research group focuses on how single cells act communally to generate an organ. Together with colleagues from the Novo Nordisk Foundation at University of Copenhagen, she and her team used a special method to watch both the activity of the gene Neurogenin 3 and the protein it makes in human pancreas cells. The researchers developed a methodology that can link the dynamic behaviors of pancreatic cells observed in live imaging movies to all the genes they express. This will contribute to a better understanding of how the hormone-producing cells of the pancreas develop.