Postdoctoral Research Fellows (m/f/d) | Molecular genetics of ageing

Scientist Cologne
Developmental and Evolutionary Biology & Genetics Structural and Cell Biology

Job Code: 27-2022

Job Offer from September 22, 2022

The Antebi Department for “Molecular Genetics of Ageing” investigates how endocrine and metabolic regulatory networks govern animal health and longevity. We primarily use the roundworm Caenorhabditis elegans and the turquoise killifish Nothobranchius furzeri as model organisms, as well as cell culture and mouse. The overarching goals are to reveal conserved, convergent mechanisms of longevity, and to understand how diet, metabolism, organellar dynamics and quality control mechanisms cooperate to promote cellular resilience. We apply a multidisciplinary approach combining genetics, systems biology, cell and molecular biology, imaging, biochemistry and mass spectrometry in order to understand the biology of ageing and age-related disease.

We seek a highly motivated and talented scientist (m/f/d) to join our enthusiastic, collaborative and diverse team in an outstanding scientific environment to take part in our exciting research.

Qualifications

The successful applicant will hold a Ph.D. in a relevant research area such as molecular biology, genetics, or biochemistry, and have a strong track record of accomplishment. Prior experience with experimentation on mouse models is required. The applicant should have a keen interest in the biology of ageing, and excellent written and oral communication skills. The working language is English; knowledge of German is not required.

Research environment

The Max Planck Institute for Biology of Ageing, Cologne, was founded in 2008 with the aim to understand fundamental mechanisms of healthy ageing in various model systems. The institute is part of a network of research institutions in the Cologne-Bonn area dedicated to research on ageing and age-related disease, constituting a vibrant and collaborative environment. Equipped with state-of-the-art technology and excellent core facilities, the institute provides outstanding research opportunities for its scientists. At the moment, we host employees from more than 35 different nations worldwide.

The employment contract will be based on the civil service code (TVöD-Bund, Tarifvertrag für den öffentlichen Dienst) and will initially be time limited. The Max Planck Society is committed to employ more disabled individuals and especially encourages them to apply. We also seek to increase the number of women in those areas where they are underrepresented and particularly encourage them to apply.

Are you interested?

Then please upload your complete application documents, containing a one-page letter with a personal statement describing your scientific accomplishments and your interests in our laboratory, your CV and bibliography, as well as contact information for 3 references, in electronic form as one single pdf-file via our online application platform. Applications will be evaluated on a rolling basis until the position is filled.

Informal inquiries are welcome and should be sent to .

Please consult recent publications from the Antebi department for more information on our scientific projects:

  • Huang W., Kew C., Fernandes S. A., Loehrke A., Han L., Demetriades C., Antebi A. (2022) Decreased spliceosome fidelity inhibits mTOR signaling and promotes longevity via an intron retention event. bioRxiv 2022.03.07.483153
  • Annibal, A., Tharyan, R.G., Schonewolff, M.F., Tam, H., Latza, C., Auler, M.M.K., Gronke, S., Partridge, L., Antebi, A. (2021) Regulation by the one carbon folate cycle as a shared metabolic signature of longevity. Nat Commun 12: 3486
  • Tharyan, R.G., Annibal, A., Schiffer, I., Laboy, R., Atanassov, I., Weber, A.L., Gerisch, B., Antebi, A. (2020) NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Nat Metab 2: 387-396
  • Gerisch, B., Tharyan, R.G., Mak, J., Denzel, S.I., Popkes-van Oepen, T., Henn, N., Antebi A. (2020) HLH-30/TFEB is a Master Regulator of reproductive quiescence. Dev Ce!! 53: 316-329
  • Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Späth, M., Suchiman, H., Eka, D., Müller, R.U., Slagboom, P.E., Partridge, L., and Antebi, A. (2017) Small nucleoli are a cellular hallmark of longevity. Nat Commun 8: 16083.
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