Research report 2021 - Max Planck Institute for Biology of Ageing
Fountain of youth for ageing stem cells in bone marrow
Max-Planck-Forschungsgruppe Chromatin und Alterung
SummaryAs we are ageing, our bones become thinner, we suffer fractures more often, and bone-diseases such as osteoporosis are more likely to occur. One responsible mechanism involves the impaired function of the bonemarrow-resident mesenchymal stem cells, which are required for the maintenance of bone integrity. We now have been able to show that these changes can be reversed by rejuvenating the epigenome. Such approach could contribute to the treatment of diseases such as osteoporosis in the future.