Yearbook 2005

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The research group Development & Disease focuses on the molecular basis by which form and structure of the skeleton are regulated during vertebrate development. Our approach combines research on human genetic disorders with gene function analysis in vitro and in animal models. The studies are carried out in close collaboration with the Institute of Medical Genetics at the Charité, Berlin. Recent advances in the identification and functional analysis of human gene mutations have provided new insights into the biology and pathology of limb malformations and, in particular, in the mechanisms of joint formation. Genetic screens have identified a large number of novel genes that are currently investigated for their role in normal bone development, in disease, and during the regeneration of bone and cartilage. more
Ribosomes translate the genetic DNA information into the amino-acid sequence of proteins and are one of the most complicated structures of the cell. High resolution methods such as X-ray analysis and cryo-electron microscopy as well as improved functional methods have led to a quantum leap in our understanding of the mechanisms of the ribosome by deducing functionality from structure. more
The numerical relativity group at the Albert Einstein Institute has recently made important contributions to the solution of the Einstein equations in regimes in which no analytic approach is possible, such as the death of a star, the birth of a black hole or the fate of a binary system of black holes. more
We present a novel definition of a unified theory of all four known fundamental forces. This definition was developed at the Max Planck Institute for Gravitational Physics (Albert Einstein Institute, AEI) and utilizes new results concerning the symmetry structures of string theory. more
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