Yearbook 2007

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The Achilles heel of nerve cells

Max Planck Institute of Neurobiology Mathey, Emily; Derfuss, Tobias; Storch, Maria; Williams, Kieran; Hales, Kimberly; Woolley, David; Al-Hayani, Abdulmonem; Davies, Stephen; Rasband, Matthew; Olsson, Tomas; Moldenhauer, Anja; Velhin, Sviataslau; Hohlfeld, Reinhard; Meinl, Edgar; Linington, Christopher
The function of the immune system is to defend against intruders such as viruses and bacteria. In case of Multiple Sclerosis, however, the immune system attacks the central nervous system. A newly found mechanism of this disease now reveals how the immune system’s antibodies can attack nerve cells directly. The results could lead to new therapy approaches for some patients. more

Aid system for aging nerve cells

Max Planck Institute of Neurobiology Kramer, Edgar; Aron, Liviu; Schulz, Jörg; Klein, Rüdiger
Parkinson disease is characterized by a massive loss of nerve cells in a specific brain region. It was shown that the Ret receptor, which is activated by the neurotrophic factor GDNF, is essential for the survival and regeneration of nerve cells in this brain region. These results advance our understanding of the molecular mechanisms in the aging brain and may facilitate the development of new therapies for Parkinson disease. more
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