In neurobiological applications, brain morphometry is termed as a description of brain structure based on imaging modalities of size, shape, and texture. Hence, morphometry promises approaches on in-vivo
characterisations of many neurological or psychiatric pathologies. This report shall outline the essential techniques of modern digital morphometry. Because structural alterations of brain tissues, as obtained by magnetic resonance imaging, are not necessarily related to a pathological process, the role of general physiological factors will be also discussed in this report.