Yearbook 2006

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Molecular approaches reveal components and mechanisms of cellular stress sensing and adaptation. In addition, mathematical modeling has proven to foster the understanding of some basic principles of signal transduction and signal processing as well as of sensitivity and robustness of information perception and cellular response. Main modeling principles are exemplified here for a model organism, the yeast Saccharomyces cerevisiae. more
After the finalization of the human genome project, investigations into the transcriptome, proteome, and metabolome have been largely increased, since their concurrence determines the functionality of genes. In this context, recent mechanistic discoveries have induced a kind of “paradigm shift” regarding the mode of action of hormones and widened our understanding of these compounds in cell and gene regulation, particularly when involved in human diseases. more
This article describes recent developments in cosmology, in particular those connected with a certain curve (referred to here as 'icon') which arises from observations of the cosmic microwave background radiation. In this context it is explained how scientists try to get a better theoretical understanding of this curve and other questions in science with the aid of mathematics, especially analysis and geometry. more
The direct observation of gravitational waves will open a new experimental field in astronomy. Several detectors have been set up around the world and LISA has been projected to complement them from space by detecting gravitational waves at low frequencies. We present here the investigations at the Max Planck Institute for Gravitational Physics on the interferometry for LISA and its precursor mission LISA pathfinder. more
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