Research report 2020 - Friedrich Miescher Laboratory of the Max Planck Society
Untangling the genome using tiny beads
Kučka, Marek; Su, Dingwen; Chan, Yingguang Frank
Friedrich-Miescher-Laboratorium für biologische Arbeitsgruppen in der Max-Planck-Gesellschaft, Tübingen
SummaryGenome sequencing holds the key to fighting disease and understanding biodiversity. However, current techniques only produce sequence fragments and omit its context, sometimes causing misleading results. We have developed haplotagging, an improved method for highly accurate sequencing at low costs while preserving the sequences context. Haplotagging can be applied to identify a single gene present in two different butterfly species living between the Amazon and the Andes which creates a unique wing pattern.