Max Planck Institute for Molecular Biomedicine

Max Planck Institute for Molecular Biomedicine

The Max Planck Institute for Molecular Biomedicine investigates the formation of cells, tissues and organs. Scientists make use of molecular-biological and cell-biological methods in a bid to discover how cells exchange information, which molecules control their behaviour and what faults in the dialogue between cells cause diseases to develop. The work of the Institute is dedicated to three closely intertwined areas. One field in which the Institute is active is stem cell research. Scientists study how stem cells can be generated and how they might be used to treat diseases. Another research area is that of inflammation processes, where one of the objectives is to fully understand the effects of blood poisoning. The third field of research is blood vessel growth, with the aim of identifying new targets for the development of therapies: blood vessels play an important role in many illnesses.

Contact

Röntgenstr. 20
48149 Münster
Phone: +49 251 70365-100
Fax: +49 251 70365-198

PhD opportunities

This institute has an International Max Planck Research School (IMPRS):
IMPRS for Molecular Biomedicine

In addition, there is the possibility of individual doctoral research. Please contact the directors or research group leaders at the Institute.

Tracking the mechanisms of artery formation
The notch signal pathway could be the basis for new therapies for cardiovascular diseases more
Stem cells leave blood vessels in areas of the bone marrow with low blood flow
Hematopoietic stem cells adhere to net-like blood vessels and transmigrate more
Restoring damaged organs back to health

First Max Planck Center for Regenerative Biomedicine opens in China

more
New stem cells for medicine
The CARE research institute in Munich is set to pursue new approaches in regenerative medicine and drug development more
Research highlights from the Yearbook
Our Yearbook 2016 showcases the research carried out at the Max Planck Institutes. We selected a few reports to illustrate the variety and diversity of topics and projects. more
A single factor from adult brain stem cells can be used to generate true cellular jacks-of-all-trades for regenerative medicine.
Postdoctoral Research Fellows
Max Planck Institute for Molecular Biomedicine, Münster June 29, 2018
Postdoctoral Research Fellow and PhD Student positions - Genomics and Vascular Biology
Max Planck Institute for Molecular Biomedicine, Münster June 29, 2018

Chromatin Architecture During Early Embryonic Development

2018 Vaquerizas, Juan M.
Cell Biology Developmental Biology Evolutionary Biology Genetics Immunobiology Infection Biology Medicine Structural Biology
The correct three-dimensional organisation of chromatin in the nucleus is a fundamental requirement for the proper functioning of the genome. As such, mutations in elements that determine this architecture lead to developmental disorders and cancer. In this work, chromatin conformation profiling in tightly staged Drosophila embryos revealed a dramatic reorganisation of chromatin that coincides with the zygotic genome activation. more

Human heart tissue from pluripotent stem cells and its applications

2017 Greber, Boris
Cell Biology Developmental Biology
Pluripotent stem cells represent an amazing tool box for generating virtually any cell tissue of the human body such as, for instance, spontaneously beating cardiac muscle tissue. How this actually works and how the process can be controlled better was recently revealed. Two regulatory switches inside the cells need to be manipulated at the right time. This surprisingly simple procedure may be used for studying the mechanisms underlying genetic cardiac disorders and for evaluating putative drugs. more

Protein folding – why speed matters

2016 Leidel, Sebastian A.
Cell Biology Developmental Biology Genetics
Proteins are the workhorses of our cells. To fulfill their roles they need to adopt a functional conformation. Scientists have now experimentally determined how fast proteins are made and have shown that the correct speed is critical for functional folding. Perturbing translation leads to protein aggregates. This can cause severe developmental defects in mice. Their brain cells receive the wrong differentiation signal due to protein stress. These results answer a fundamental question of molecular biology and have far reaching consequences for neurodegenerative diseases and biotechnology. more

Blood vessels in the skeletal system control bone formation

2015 Kusumbe, Anjali P.; Ramasamy, Saravana K.; Adams, Ralf H.
Cell Biology Developmental Biology

Blood vessels provide the whole organism with essential oxygen and nutrients, but are also an important source of regulatory cues in many organs. In the skeletal system, specialized capillaries release signals that control bone-forming progenitor cells and thereby bone growth. The aging organism lacks such specialized blood vessels and shows a detrimental decline in bone renewal. New results indicate that the stimulation of blood vessel growth in such conditions might be therapeutically beneficial.

more

How differences in blood flow influence blood vessel network formation

2014 Siekmann, Arndt
Cell Biology Developmental Biology Genetics
Our heart pumps blood through an interconnected network of tubules to all parts of our body. This is important for the optimal availability of oxygen to every organ. How does the vasculature ensure the optimal connectivity between blood vessels? Scientists from the Max Planck Institute for Molecular Biomedicine show that differences in blood flow can control the proper sprouting and pruning of blood vessels. These discoveries could provide answers to the question why in certain disease settings, blood is not delivered efficiently. more
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