Max Planck Institute  for Heart and Lung Research

Max Planck Institute for Heart and Lung Research

Scientists at the Max Planck Institute for Heart and Lung Research study the structure and workings of the heart, blood vessels and lungs. Among other things, their findings are intended to contribute to a better understanding of diseases in these organs and in developing of possible treatments. The scientists, for example, examine how cells in the heart, blood vessel or lung tissue communicate with each other, and which signal molecules influence their function. They also look into the question of how function can be restored to damaged tissue. Stem cells – in other words precursor cells that can grow into specialised heart, blood vessel or lung cells – are therefore another important field of research for the Institute. In the future, these stem cells could, for instance, help to minimise tissue damage in heart attack patients or people with lung disease.

Contact

Ludwigstr. 43
61231 Bad Nauheim
Phone: +49 6032 705-0
Fax: +49 6032 705-1604

PhD opportunities

This institute has an International Max Planck Research School (IMPRS):
IMPRS for Heart and Lung Research

In addition, there is the possibility of individual doctoral research. Please contact the directors or research group leaders at the Institute.

Pulmonary fibrosis caused by single transcription factor
Reduced FoxO3 activity reprograms connective tissue cells, triggering the disease more
Lung cancer triggers pulmonary hypertension
Nearly half of all advanced-stage lung cancer patients develop arterial pulmonary hypertension more
Cancer diagnosis with a breath test
A new test for the early detection of lung cancer measures tiny changes in the composition of the breath more
Oestrogen receptor causes weight loss in male mice
The receptor increases energy consumption by muscle cells and prompts weight loss more
The PIEZO1 cation channel translates mechanical stimulus into a molecular response to control the diameter of blood vessels more

A Repairable Heart

3/2014

Biology & Medicine

Newts possess the almost magical ability to regenerate damaged tissue, making them unique among vertebrates. Thomas Braun of the Max Planck Institute for Heart and Lung Research in Bad Nauheim is studying the amphibians to learn how an organism can regrow entire organs. Perhaps one day it will help enhance the capacity for regeneration in humans.
The advances made by Werner Seeger and his team in the treatment of pulmonary hypertension mean that many patients
at least live longer, with a better quality of life.

Breath test enables early detection of lung cancer

2018 Barreto, Guillermo
Developmental Biology Genetics Immunobiology Medicine Physiology
Lung cancer is the leading cause of death from cancer globally. One reason for this is that early signs and symptoms are unspecific and most lung tumors are recognized at an advanced stage. The Max Planck scientists have developed a test to detect lung cancer in early stages. It is based on the detection of genes that are active in tumor cells, but not in healthy lung cells. more

From lung development to lung regeneration

2017 Ahlbrecht, Katrin; Morty, Rory E.; Samakovlis, Christos; Seeger, Werner
Developmental Biology Immunobiology Physiology

Impairment of gas exchange due to malformation or disruption of the alveoli represents a key hallmark of structural lung diseases. There is no curative therapy available. The recovery of an intact lung structure represents a desirable option in the development of therapeutic concepts. The current knowledge about the formation of new alveoli during lung development and during compensatory lung growth of the adult lung serves as a basis for the identification of target cells and molecules which are capable to induce the formation of new alveoli in the diseased lung.

more

miRNAs control essential functions of the cardiovascular system

2016 Böttger, Thomas
Cell Biology Medicine Physiology
The primary function of miRNAs is the posttranscriptional regulation of gene expression. The functional analysis of miRNA-mediated regulation allows fascinating insights into complex regulatory interactions. A group at the MPI of Heart and Lung Research investigates miRNA-dependent molecular mechanisms in contractile tissues of the cardiovascular system. The work reveals basic principles of miRNA regulation and answers fundamental questions related to development and physiology of the cardiovascular system. more

G-protein-mediated signaling cascades in the cardiovascular and immune system

2015 Wettschureck, Nina
Developmental Biology Evolutionary Biology Genetics Immunobiology Infection Biology Medicine Physiology
Heterotrimeric G-proteins transduce signals from activated G-protein-coupled receptors to intracellular signaling cascades. Scientists at the MPI for Heart and Lung Research have a longstanding interest in the role of the families Gq/G11 and G12/G13, their upstream activators and downstream effectors, in cardiovascular and immunological functions. The long-term goal of their work is to identify new targets for the treatment of chronic cardiovascular and immune disease. more

The ERBB2 receptor: a necessary proto oncogene

2014 Reischauer, Sven
Developmental Biology Genetics Medicine

During development cardiac morphogenesis relies on the concerted activity of several growth factor receptors including the proto oncogene ERBB2. In adults, its cardiotoxicity causes severe side effects in anti-ERBB2 cancer therapies. Therefore we developed a transgenic zebrafish line to elucidate the role of ErbB2 signaling in cardiomyocytes. Using this novel tool combined with state-of-the-art microscopy, we were able to identify ErbB2 as a mediator of remodeling of the contractile machinery, an unexpected mechanism with potentially important implications to human health.

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