Max Planck Institute  for Heart and Lung Research

Max Planck Institute for Heart and Lung Research

Scientists at the Max Planck Institute for Heart and Lung Research study the structure and workings of the heart, blood vessels and lungs. Among other things, their findings are intended to contribute to a better understanding of diseases in these organs and in developing of possible treatments. The scientists, for example, examine how cells in the heart, blood vessel or lung tissue communicate with each other, and which signal molecules influence their function. They also look into the question of how function can be restored to damaged tissue. Stem cells – in other words precursor cells that can grow into specialised heart, blood vessel or lung cells – are therefore another important field of research for the Institute. In the future, these stem cells could, for instance, help to minimise tissue damage in heart attack patients or people with lung disease.

Contact

Ludwigstr. 43
61231 Bad Nauheim
Phone: +49 6032 705-0
Fax: +49 6032 705-1604

PhD opportunities

This institute has an International Max Planck Research School (IMPRS):

IMPRS for Heart and Lung Research

In addition, there is the possibility of individual doctoral research. Please contact the directors or research group leaders at the Institute.

Mechanical stimulus, biological response: Cation channel PIEZO 1 mediates release of Andromedullin

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Earliest step of lymphatic system formation discovered

Lymphatic endothelium has same embryonic origin as skeletal muscle

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When lung cells are out of breath

RASSF1A and HIF-1alpha stimulate Warburg effect in cancer and pulmonary hypertension

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Genetic defects without consequences

mRNA of defective genes pushes compensation mechanism

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Transformation of adult stem cells causes tumours

Transcription factors of the Dux family in active muscle stem cells can trigger muscle tumour formation

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Scientists from 100 countries of the world work at the Max Planck Institutes. Here they write about their personal experiences and impressions. Mohamed El-Brolosy from Cairo is a doctoral student at the Max Planck Institute for Heart and Lung Research in Bad Nauheim. He talks about the cultural and structural differences between Germany and Egypt, explains the bureaucratic obstacles that can hinder research in Egypt, and describes how karate is helping him improve his German.

A Repairable Heart

3/2014

Biology & Medicine

Newts possess the almost magical ability to regenerate damaged tissue, making them unique among vertebrates. Thomas Braun of the Max Planck Institute for Heart and Lung Research in Bad Nauheim is studying the amphibians to learn how an organism can regrow entire organs. Perhaps one day it will help enhance the capacity for regeneration in humans.

The advances made by Werner Seeger and his team in the treatment of pulmonary hypertension mean that many patients at least live longer, with a better quality of life.

Postdoctoral Researcher - Reference Number 09_2019

Max Planck Institute for Heart and Lung Research, Bad Nauheim April 24, 2019

Regulation of Notch signaling dynamics by deubiquitinating enzymes

2018 Potente, Michael

Developmental Biology Genetics Physiology

The Notch signaling pathway is a highly conserved cell-cell communication mechanism that governs the development of and function of body tissues. We found that the enzyme USP10 is a novel regulator of this pathway, whose activity is particularly important for the growth of new blood vessels. Our studies revealed new insights into the molecular fundamentals of blood vessel development and could also have relevance for other physiological and pathological processes in which Notch signaling pathway plays a pivotal role.

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Breath test enables early detection of lung cancer

2017 Barreto, Guillermo

Developmental Biology Genetics Immunobiology Medicine Physiology

Lung cancer is the leading cause of death from cancer globally. One reason for this is that early signs and symptoms are unspecific and most lung tumors are recognized at an advanced stage. The Max Planck scientists have developed a test to detect lung cancer in early stages. It is based on the detection of genes that are active in tumor cells, but not in healthy lung cells.

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From lung development to lung regeneration

2016 Ahlbrecht, Katrin; Morty, Rory E.; Samakovlis, Christos; Seeger, Werner

Developmental Biology Immunobiology Physiology

Impairment of gas exchange due to malformation or disruption of the alveoli represents a key hallmark of structural lung diseases. There is no curative therapy available. The recovery of an intact lung structure represents a desirable option in the development of therapeutic concepts. The current knowledge about the formation of new alveoli during lung development and during compensatory lung growth of the adult lung serves as a basis for the identification of target cells and molecules which are capable to induce the formation of new alveoli in the diseased lung.

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miRNAs control essential functions of the cardiovascular system

2015 Böttger, Thomas

Cell Biology Medicine Physiology

The primary function of miRNAs is the posttranscriptional regulation of gene expression. The functional analysis of miRNA-mediated regulation allows fascinating insights into complex regulatory interactions. A group at the MPI of Heart and Lung Research investigates miRNA-dependent molecular mechanisms in contractile tissues of the cardiovascular system. The work reveals basic principles of miRNA regulation and answers fundamental questions related to development and physiology of the cardiovascular system.

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G-protein-mediated signaling cascades in the cardiovascular and immune system

2014 Wettschureck, Nina

Developmental Biology Evolutionary Biology Genetics Immunobiology Infection Biology Medicine Physiology

Heterotrimeric G-proteins transduce signals from activated G-protein-coupled receptors to intracellular signaling cascades. Scientists at the MPI for Heart and Lung Research have a longstanding interest in the role of the families Gq/G11 and G12/G13, their upstream activators and downstream effectors, in cardiovascular and immunological functions. The long-term goal of their work is to identify new targets for the treatment of chronic cardiovascular and immune disease.

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