Two open PhD-student positions

Young Researchers Dortmund
Structural and Cell Biology Physiology Chemistry

Job Code: 08/19

Job Offer from February 07, 2019

Two open PhD-student positions in RNA Biology at Chemical Genomics Center of the Max Planck Society in Dortmund, Germany.

The newly established Imig research group at the CGC/MPI seeks for two highly motivated PhD-students with strong interest in RNA Biology. Anticipated starting date is July-August 2019, or on individual basis.

The group will be embedded into the “Chemical Genomics Centre” (CGC), which was established in 2005 by the Max-Planck Society (MPG) in close collaboration with Astra Zeneca, Merck KGaA and Pfizer. Our mission is to address challenging scientific problems, to explore and validate high-risk approaches and to generate cutting edge precompetitive research, which could enable the development of translational science in the medium to long term. The CGC network interconnects the scientific, infrastructural and institutional strength of well-established Max-Planck Departments with new research groups bringing in intellectual talent and novel scientific approaches. It will serve as a role model for excellent and fruitful collaborations between academic research and industry again in the third funding period (2018-2023). For more information about the CGC and its track record see: www.cgc.mpg.de.

The group will be located in the well-equipped laboratories in the BioMedizinZentrum (BMZ) Dortmund. The BMZ is situated in the Technische Universität Dortmund Campus, where it benefits from a strong collaborative, inter-sectorial network of R&D entities such as the Max Planck Institute of Molecular Physiology (MPI), the Lead Discovery Center (LDC), the Technische Universität Dortmund (TUDo), the Compound Management and Screening Center (COMAS), the Zentrum für Integrierte Wirkstoffforschung (ZIW).

Requirements

Successful candidates holding M.Sc. or equivalent degree will have a strong background in Chemical Biology, Cell/Molecular Biology, Biochemistry or a related area. Basics in Genetics and in particular experience with the application of CRISPR/Cas9 gene editing system will be a surplus. Background in bioinformatics are desirable, but not mandatory. The particular focus of the strongly collaborative projects will be the application and extension of newly establish genome-wide microRNA (miRNA) targetome identification tool “miR-CLIP” (Imig et. al. Nat. Chem. Biol. 2014: https://www.nature.com/articles/nchembio.1713) to study long non-coding (lncRNA)-miRNA regulatory networks in cancer in a systems wide fashion. The overall goal will be to identify and characterize potentially druggable RNA structures for future therapeutic application. CRISPR/Cas9 genome edition tool approach will be essential for a functional characterization of those targets. The working language is English.

Our offer / your application

The remuneration will be in the amount of 50% of salary group 13 level 1 of the Collective Wage Agreement for the Civil Service Bund (TVÖD-Bund).

A higher level, but only up to a maximum of level 2 can be reached in accordance with the provisions of the Collective Wage Agreement for the Civil Service Bund (TVöD-Bund).

Candidates are invited to submit their applications including CV, publication list (if applicable), in English, and two to three letters of recommendation to be sent to Dr. Debora Bruzzese email: , who can also be contacted for additional information.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.

Furthermore, the Max Planck Society seeks to increase the number of women in areas where they are underrepresented and therefore explicitly encourages women to apply.

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