Research report 2010 - Max Planck Research Unit for Enzymology of Protein Folding
Just one of many cyclophilins – isoenzyme - specific inhibition
Authors
Schiene-Fischer, Cordelia
Departments
Max-Planck-Forschungsstelle für Enzymologie der Proteinfaltung, Halle
Summary
Cyclophilins belong to the enzyme class of peptidyl prolyl cis/trans isomerases which catalyze the cis/trans isomerization of prolyl bonds in peptides and proteins in different folding states. Among the 18 human cyclophilin isoenzymes, the two most abundant members of the cyclophilin family CypA and CypB exhibit specific cellular functions in several inflammatory diseases, cancer development and HCV replication. A small-molecule inhibitor on the basis of aryl 1-indanylketones has now been shown to discriminate between CypA and CypB.