Research report 2018 - Max Planck Institute of Neurobiology

Designer Proteins for Brain Research

Authors
Griesbeck, Oliver
Departments
Forschungsgruppe Tools for Bio-Imaging
Summary
Directed evolution of proteins in vitro harbors great potential to generate tailor-made tools for applications in neuroscience. Our group has built an imaging-based screening platform that allows high throughput validation of hundred thousands of protein variants expressed in bacteria. We have used the platform to optimize a fluorescent protein that is particularly useful for labeling structures that are located deep within the brain.

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