Research report 2017 - Max Planck Institute of Biochemistry
Oxeiptosis – a ROS induced caspase-independent apoptosis-like cell death pathway
Holze, Cathleen; Benda, Christian; Hubel, Philipp; Pennemann, Friederike L.; Pichlmair, Andreas
Forschungsgruppe Angeborene Immunität
SummaryReactive oxygen species (ROS) are commonly generated during virus infections, but their significance is only partially understood. We identified a cell death pathway, oxeiptosis, regulating cell death and cell survival after exposure to ROS. Manipulation of oxeiptosis impairs ROS - and virus - induced cell death in vitro and causes lung inflammation and tissue injury in influenza A infected mice. Since ROS are commonly generated during physiologic and pathologic situations, we anticipate that oxeiptosis plays a prominent role in attenuating a wide range of diseases.