Research report 2017 - Max Planck Institute for Dynamics of Complex Technical Systems
Computer-aided design of microbial cell factories
Steffen Klamt, Björn-Johannes Harder, Axel von Kamp
Max Planck Institute for Dynamics of Complex Technical Systems, Magdeburg
SummaryA key principle for the rational design of cell factories is the stoichiometric coupling of growth and product synthesis, which makes production of the desired compound obligatory for growth. Using mathematical models and new computational algorithms, researchers at the Max Planck Institute in Magdeburg showed that coupling of growth and production is feasible under appropriate genetic interventions for almost all metabolites in five major production organisms. These results are of fundamental importance for rational metabolic engineering in biotechnology.