The Department for „Molecular Genetics of Ageing“ headed by director Prof. Dr. Adam Antebi at the Max Planck Institute for Biology of Ageing is looking for full time Postdoctoral Research Fellows (job code 27-2017).
The Antebi Department for “Molecular Genetics of Ageing” investigates how diet, reproduction, and hormones impact animal life span, mostly using the worm Caenorhabditis elegans as a model organism. The overarching goals are to reveal conserved and convergent mechanisms of longevity, and to understand how hormones and small molecule metabolites affect metabolism, signal transduction and ageing. We apply a multidisciplinary approach combining, genetics, systems biology, cell and molecular biology, imaging, biochemistry and mass spectrometry in order to understand the biology of ageing and age-related disease.
We seek a highly motivated, ambitious, and talented scientist to join an enthusiastic and collaborative team in an outstanding scientific environment to perform research on longevity mechanisms in a worm model system. The research topic will most likely revolve around the functions and regulations of the nucleolus during the aging process.
The successful applicant will hold a Ph.D. in a relevant research area such as molecular biology, genetics, or biochemistry and has a strong track record of accomplishment. Prior experience with model organisms (yeast, worm, fly, mouse) would be welcome, but are not required. The applicant should have a keen interest in the biology of ageing, and excellent written and oral communication skills. The working language is English; knowledge of the German language is not required.
The Max Planck Institute for Biology of Ageing (MPI-AGE), Cologne, was founded in 2008 with the aim to understand fundamental mechanisms of healthy ageing in various model systems. The institute is part of a broad network of research institutions in the Cologne-Bonn area dedicated to research on ageing and age-related disease, constituting a vibrant and collaborative environment with state of the art facilities for research. Currently we host more than 250 employees from more than 30 different nations.
The employment contract will be based on contracts for the civil service (TVöD-Bund, Tarifvertrag für den öffentlichen Dienst and will initially be time limited. The Max Planck Society is committed to employ more disabled individuals and especially encourages them to apply. We also seek to increase the number of women in those areas where they are underrepresented and particularly encourage them to apply.
Then please upload your complete application documents, containing a one-page letter with a personal statement describing your scientific accomplishments and your interests in our laboratory, your CV and bibliography as well as, contact information for 3 references, in electronic form as one single pdf-file via our online application platform until December 31st 2017.
Please also consult recent publications from the Antebi department for more information on our scientific projects:
Tiku, V., Jain, C., Raz, Y., Nakamura, S., Heestand, B., Liu, W., Späth, M., Suchiman, H., Eka, D., Müller, R.U., Slagboom, P.E., Partridge, L., and Antebi, A. (2017)
Small nucleoli are a cellular hallmark of longevity. Nat Commun- 8: 16083.
Nakamura, S., Karalay, Ö., Jäger, P.S., Horikawa, M., Klein, C., Nakamura, K., Latza, C., Templer, S.E., Dieterich, C., and Antebi, A. (2016)
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.
Nat Commun. 7:10944.
Denzel, M.S., Storm, N.J., Gutschmidt, A., Baddi, R., Hinze, Y., Jarosch, E., Sommer, T., Hoppe, T., and Antebi, A. (2014).
Hexosamine pathway metabolites enhance protein quality control and prolong life.
Cell 156, 1167-1178.
Horn, M., Geisen, C., Cermak, L., Becker, B., Nakamura, S., Klein, C., Pagano, M., and Antebi, A. (2014).
DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.
Developmental cell 28, 697-710.