Research report 2017 - Max Planck Florida Institute for Neuroscience

CRISPR/Cas9-based genetic editing of mature neurons in the brain

Yasuda, Ryohei
Arbeitsgruppe Neuronale Signalübertragung
The CRISPR/Cas9-method allows precise and efficient editing of the cellular genome, with to date unmatched simplicity and speed. So far, however, CRISPR/Cas9 could not be used directly in the brain, because the method does not work properly on mature neurons. We recently discovered that by combining CRISPR/Cas9 with a virus, the method’s efficiency can be increased by several orders of magnitude, enabling the use even in mature neurons – irrespective of cell type, brain region or age.

For the full text, see the German version.

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