PhD Position

Max Planck Institute of Biophysics, Frankfurt am Main

Developmental and Evolutionary Biology & GeneticsStructural and Cell Biology

Type of Job

Scientist

PhD Position - Algorithm Development/Image processing for Cryo-EM

Job Offer from October 11, 2017

A PhD position is available in the group of Misha Kudryashev at the Max Planck Institute of Biophysics and the Buchmann Institute for Molecular Life Science at Goethe University, Frankfurt am Main, Germany.

The research

The project focuses on a set of challenging problems in registration of noisy three-dimensional data with anisotropic resolution. The data comes from cryo electron tomograms and contain important information about structure of important biological molecules. The developing potential of cryo-EM is widely acknowledged, including the Noble Prize in 2017. The main objective of the project is to set up the algorithmic and engineering workflow to extract maximum information by subtomogram averaging from cryo electron tomograms.

During the course of the project the applicant will extend the GPU-based parallel computing approach using the Matlab-based system Dynamo. Further development steps involve algorithm design and implementation, construction of efficient OOP data structures to support optimization in HPC environments, tuning data storage and accessing systems for management and visualization of large sets of three-dimensional data, and enabling flexible prototyping for fast testing of new algorithmic approaches. At the advanced stages of the project application of modern methods for Computer Vision and Machine Learning will be explored. The developed methods will be used for determination of structure of membrane proteins from the human brain, which are important for neurological disorders.

Your profile

The candidate should have a Master or Diploma degree in Physics, Engineering, Mathematics or a related discipline and programming skills with any of C++ / Python / Matlab / CUDA. A background in biology is not required. The successful candidate will take part in a PhD program.

Our offer

The Max Planck Institute for Biophysics in Frankfurt is one of the top places in the world to study structure of membrane proteins. The institute departments combine cryo electron microscopy, X-ray crystallography, biophysics and theoretical methods to gain insights into structure and function of fundamentally important biological processes. The Kudryashev group has access to excellent laboratory facilities, high-performance computing infrastructure (large CPU and GPU-clusters) and high-end electron microscopes (2xFEI Titan Krios, Polara, F30 and JEOL 3200FSC) equipped with direct electron detectors.

The initial contract duration is 3 years with an optional extension. Working language is English.

Your application

The Max Planck Society aims at increasing the percentage of women in research positions and strongly encourages women to apply. The Max Planck Society is an equal opportunity employer and particularly welcomes applications from individuals with disabilities.

Candidates should send a single pdf-file including a one-page motivation letter, the CV and the names of two principal investigators from whom reference letters can be obtained. Please send to .

Informal inquiries are welcome.

Application deadline: Dec 1st 2017, early-bird applications are welcome, starting date is flexible.

Max Planck Institute of Biophysics
Max-von-Laue-Straße 3
60438 Frankfurt am Main
Germany

 
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