Yearbook 2017

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Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors

Max Planck Institute for Molecular Genetics Risch, Thomas; Abdavi-Azar, Nilofar; Jandrasits, Christine; Amstislavskiy, Vyacheslav; Worth, Catherine L.; Warnatz, Hans-Jörg; Sultan, Marc; Herwig, Ralf; Lehrach, Hans; Yaspo, Marie-Laure; in Kooperation mit dem OncoTrack Konsortium (www.oncotrack.eu)
Colorectal carcinomas (CRC) are clinically challenging tumors. To identify novel predictive biomarkers of the therapeutic response, the OncoTrack consortium recruited 106 CRC patients for establishing a biobank of organoids and xenografts models analysed by sequencing and tested in a pre-clinical platform. This unique resource generated a compendium of data for advancing our understanding of CRC. Linking molecular patterns with drug response profiles identified novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab. more

Numerically intensive simulations on an integrated computing infrastructure

Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen (GWDG) Brücher, Martina(1); Ehlers, Tim(1); End, Vanessa(1); Köhler, Christian(1); Korte, Fabian(2)(1): Gesellschaft für wissenschaftliche Datenverarbeitung mbH Göttingen(2): Universität Göttingen, Institut für Informatik
Cloud services, high-performance computing (HPC) clusters, computers with special accelerator cards? The selection of the optimal application and computing resource is a success factor for scientific simulations. In view of the heterogeneous infrastructure of modern data centers, this is often tricky. Learning the technical details is time-consuming. The aim of the cooperation project launched in 2016 between GWDG and the Simulation Science Center Clausthal-Göttingen is to automate the selection and provision of the resource. more
Over 100 years after the formulation of the theory of general relativity by Albert Einstein and more than 30 years after the first discovery of a binary neutron star system, the gravitational wave signal of colliding neutron stars has been detected for the first time. more
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