Research report 2016 - Max Planck Institute for Dynamics of Complex Technical Systems
Development of a novel tubular bioreactor for continuous production of influenza virus vaccines
Tapia, Felipe; Genzel, Yvonne; Reichl, Udo
SummaryAn increasing world population and fast spread of old and new influenza virus strains demands more efficient vaccine production methods. One approach is the use of coupled continuous bioreactors. Unfortunately, accumulation of defective interfering particles (DIPs) leads to unstable virus yields. As an alternative we have designed a novel plug-flow tubular bioreactor system, providing high influenza virus titers for up to three weeks in continuous mode using suspension MDCK cells. This novel platform can be used for other viruses and help reduce vaccine manufacturing costs worldwide.