Research report 2016 - Max Planck Institute of Psychiatry
Human-derived cerebral organoids for investigating human cortical malformations
Abteilung für Entwicklungs-Neurobiologie
SummaryMalformations of the cerebral cortex are often associated with intellectual disability and epilepsy. These disorders arise in the course of cortical development as a consequence of disturbance of neuronal development, migration and connection. In order to develop therapeutic strategies, it is essential to understand the genetic causes and to investigate the molecular and cellular mechanisms underlying these malformations. The MPI research group uses cerebral organoids derived from induced stem cells for this purpose.