Research report 2016 - Max Planck Institute of Immunobiology and Epigenetics
Enlightening organelle function - live cell imaging reveals insight into metabolic communication strategies of immune cells
Forschungsgruppe Organelle Communication Immunology
SummaryIn response to pathogens, immune cells activate a cellular program to eliminate harmful, infectious organisms and ensure our health. To mount a functional immune response, most immune cells require the reprogramming of their metabolic pathways. The scientists aim at gaining novel insight into how specific cellular compartments, so-called organelles, regulate such metabolic transitions. Of particular interest is hereby not only the function of individual organelles but also how inter-organellar communication drives metabolic immune cell programs and enables the fight against infections.