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Beteiligte Max-Planck-Institute |
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MPI für medizinische Forschung |
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Autoren |
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Urban, N. N.; González-Burgos, G. R.; Henze, D. A.; Lewis, D. A.; Barrionuevo, G. |
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Publikationstyp |
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Artikel |
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Titel |
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Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex
(Selective reduction by dopamine of excitatory synaptic inputs to pyramidal neurons in primate prefrontal cortex) |
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Zusammenfassung |
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We have employed in vitro physiological methods to investigate dopaminergic modulation of excitatory synaptic transmission in monkey prefrontal cortex (PFC) circuits. We show that combined activation of D1-like and D2-like dopamine receptors results in the reduction of extracellular stimulation-evoked isolated EPSCs in layer 3 pyramidal neurons. Using paired recordings from synaptically connected pyramidal neurons we have determined the basic properties of unitary synaptic connections between layer 3 pyramids in the primate PFC and, interestingly, we found that dopamine does not reduce synaptic transmission between nearby pairs of synaptically coupled PFC pyramidal neurons. This input specificity may be a critical aspect of the dopaminergic regulation of recurrent excitatory circuits in the PFC. |
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Quelle |
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Journal of Physiology 539 (3), 707-712 (2002) |
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Sprache |
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English |
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Rechte |
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© Copyright 2002 The Physiological Society |
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Identifikation |
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URI http://www.jphysiol.org/cgi/content/full/539/3/707
URI http://www.jphysiol.org/cgi/content/abstract/539/3/707
URI http://www.jphysiol.org/cgi/reprint/539/3/707
DOI 10.1113/jphysiol.2001.015024 |
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Relation |
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http://www.jphysiol.org/cgi/external_ref?access_num=1709528&link_type=MED
http://www.jphysiol.org/cgi/ijlink?linkType=ABST&journalCode=jneuro&resid=15/12/7821 |
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