Prof. Dr. Ulrich Benjamin Kaupp
caesar (center of advanced european studies and research), BonnPhone: +49 228 9656-273
Fax: +49 228 9656-111
Email: u.b.kaupp@caesar.de
Luis Alvarez, Ph.D.
Department of Molecular Sensory Systems/Molekulare Neurosensorik
caesar (center of advanced european studies and research), BonnPhone: +49 228 9656-354
Email: luis.alvarez@caesar.de
Stefan Hartmann
caesar (center of advanced european studies and research), BonnPhone: +49 228 9656-292
Fax: +49 228 9656-9292
Email: stefan.hartmann@caesar.de
Cell Biology
Sperm can do calculus!
March 07, 2012
The swimming path on which sperm follow the mating call of the egg, varies according to species. Sperm – in particular those of marine species – swim along convoluted paths in a chemical concentration gradient. Their swimming style is controlled by the calcium ions in the sperm tail. It was previously believed that at high calcium concentration, the sperm tails make asymmetrical, whip-like movements and their swimming path is very curved, while at low calcium concentration, the tail beats symmetrically and sperm swim on a straight line. The alternation of high and low calcium concentrations was thought to steer sperm along spiral-shaped swimming paths. However, this simple model was in contradiction with experiments on freely-swimming sperm and presented the investigators with something of a mystery.
The scientists have now succeeded into solving this mystery. Using an ingenious stroboscopic laser illumination – similar to that used in discotheques – the project leader Luis Alvarez was able to trace the movement of sperm in detail, and simultaneously measure the changes in the calcium concentration. The result was astonishing: the sperm tail only reacted to the time derivative of the calcium concentration and the absolute concentration was of little relevance. To put it simply: sperm can perform calculus! Exactly how they do this is unclear. The caesar scientists suspect that sperm detect calcium ions with the help of two proteins. Calcium binds to one protein fast and to the other slow. By comparing the amount of calcium bound on both proteins can compute a “chemical derivative”, so to speak.
But why do sperm carry out this complicated calculation that we first encounter at the upper secondary school level? The concentration of the attractants and, therefore also, the calcium concentration in sperm is very high near the egg. The mathematical trick probably enables sperm to be able to react even in the presence of such high calcium concentrations.
Apart from calcium, many other intracellular messenger control cell functions. Is it therefore possible that, cells in general, also perform complex chemical calculations involving other intracellular messengers? The scientists at Bonn would like to address this important question in the future.
