Dr. Christina M. Nielsen-Marsh
Max Planck Institute for Evolutionary Anthropology, LeipzigPhone: +49 355 0361
Fax: +49 355 0399
Email: nielsen@eva.mpg.de
Prof. Michael Richards
Department of Human Evolution
Max Planck Institute for Evolutionary Anthropology, LeipzigPhone: +49 341 355-0352
Email: richards@eva.mpg.de
Prof. Erik Trinkaus
http://www.wustl.eduPhone: +1 314 935-5207
Fax: +1 314 935-5207
Email: trinkaus@wustl.edu
Evolutionary Biology
Oldest Fossil Protein Sequenced
March 08, 2005
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The research, published in PNAS, presents the sequence for the bone protein osteocalcin from a Neanderthal from Shanidar Cave, Iraq, as well as osteocalcin sequences from living primates (humans, chimpanzees, gorillas and orangutans). The team found that the Neanderthal sequence was the same as modern humans. In addition, the team found a marked difference in the sequences of Neanderthals, human, chimpanzee and orangutan from that of gorillas, and most other mammals. This sequence difference is at position nine, where the crystalline amino acid hydroxyproline is replaced by proline (an amino acid that is found in many proteins). The authors suggest that this is a dietary response, as the formation of hydroxyproline requires vitamin C, which is ample in the diets of herbivores like gorillas, but may be absent from the diets of the omnivorous primates such as humans and Neanderthals, orangutans and chimpanzees. Therefore, the ability to form proteins without the presence of vitamin C may have been an advantage to these primates if this nutrient was missing from the diets regularly, or from time to time.
This research opens up the exciting possibility of extracting and sequencing protein from other fossils, including earlier humans, as a means of determining the relationships between extinct and living species, and to better understand the phylogenetic relationships.
