Prof. Dr. Franz-Ulrich Hartl
Max Planck Institute of Biochemistry, MartinsriedPhone: +49 89 8578-2244
Fax: +49 89 8578-2211
Email: uhartl@biochem.mpg.de
Anja Konschak
Presse- und Öffentlichkeitsarbeit
Max Planck Institute of Biochemistry, MartinsriedPhone: +49 89 8578-2824
Fax: +49 89 8578-3777
Email: konschak@biochem.mpg.de
September 12, 2011
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Hartl and Horwich discovered that not all proteins can fold inside cells by themselves. They determined that a protein called Chaperonin acts as a cage-like folding “machine” that provides a safe place for proteins to fold, away from outside interference. “By unraveling the mysterious workings of these amazing machines, the researchers gave the medical world a key understanding of how proteins reach their biological potential”, said Maria C. Freire, President of the Lasker Foundation. Because faulty proteins also play a role in neurodegenerative diseases such as Alzheimer’s or Parkinson, Hartl’s results could contribute significantly to developing new drugs for the treatment of these diseases.